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15 Natural Anti-Histamines & Mast Cell Stabilizers

2/1/2021

40 Comments

 
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In functional medicine, we always want to be looking upstream and trying to gather as many clues and evidence through testing and intake to determine what is at the root cause of the chronic symptoms in question.

We then work to treat and resolve the underlying problem(s) and this helps to reduce symptoms and restore health long term. But what happens when someone is reacting to or not tolerating the treatment needed to resolve their root cause problems?

This is the biggest challenge I see for those who have MCAS and histamine intolerance.  Their immune systems are so hyper-reactive and overly sensitive that they will often have trouble tolerating the treatment needed to resolve the root cause issues like parasites, lyme, SIBO, retroviruses, or mold. 

I experienced this personally when I was being treated for Lyme disease and mold illness aggressively for 2 years before knowing that MCAS was playing a role in my symptoms. My MCAS manifested as extreme body pain, even after 2 years of Lyme disease treatment my pain wasn't getting any better, in fact, it was getting worse!!  I also found myself becoming very sensitive and reactive to foods, smells, chemicals, EMF's, and even most of the medications and supplements that were treating my illness.  I could not tolerate treatment and was just getting sicker and feeling worse. 

​Figuring out I had MCAS and adding in both pharmaceutical and natural anti-histamines and mast cell stabilizers was a game changer for me. My pain levels dropped slowly, my energy improved, my rashes disappeared and my food reactions lessened. Overtime I finally started to be able to tolerate the treatment I needed to resolve my root 
causes. 

After my personal experience and professionally working with lots of mast cell clients, I now understand that its imperative to get the immune system to calm down and be less reactive before you will be able to tolerate treatment for and resolve what's at the root cause of your MCAS.

My practice is now 90% MCAS patients and every client is unique in what combination of anti-histamines and mast cell stabilizers work to calm down the immune response and be less reactive.

I use special lab testing to help give me clues about each clients bio-individual triggers, metabolism, and root cause issues. This helps me make educated recommendations in the area of natural anti-histamines and mast cell stabilizers that will work for each personal individually. 

There are some nuances to choosing the right combination of supplements and it often takes some trail and error. This is why I highly recommend working with a practitioner who knows and understands this well to help guide your choices.

You will want to choose clean formulations with minimal or no fillers.  I suggest single active ingredient items so that you know what is helping or hurting you.

If you are someone who has food reactions, you will want to time these items to be taken 15-30 minutes prior to meals. This timing can help to reduce post meal time mast cell reactions. 

Lastly, never try more than one of these at the same time.  Always try anything that is new to you alone with no other changes or adjustments in food or medications, titrate up to the recommended dose (or your tolerated dose) slowly and then add the next item. I typically recommend a 3 day trial before increasing the dose or adding the next supplement. 

Here are the natural options that I use most in my practice...
15 Natural Anti-Histamines & Mast Cell Stabilizers:
  1. Quercetin - a bioflavonoid that is likely the most used and well known anti-histamine and natural mast cell stabilizer. It is sourced from either citrus or onion & garlic family.  Tip: People who have salicylate intolerance will sometimes not tolerate quercetin well. 
    Recommended Brands: Pure Encapsulations Quercetin
    Recommended Dose: Start with 250mg once/day and work up to 500mg 3 times/day

  2. Luteolin - a bioflavonoid that is usually extracted from artichokes that is a potent mast cell stabilizer and natural anti-histamine. I find it works well to reduce neurological symptoms like anxiety, insomnia, irritability, fatigue and brain fog. 
    Recommended Brands: Young Nutraceuticals Mirica, Mirica Advanced, & Luteolin Complex*
    Recommended Dose: Start with 25mg once daily and work up to 25-50mg 3 times/day

    *To order Mirica, Mirica Advanced, or Luteolin Complex, click here.

  3. Perilla Extract - comes from perilla seed and the extract contains two potent ingredients: luteolin and rosmarinic acid that have the ability to modulate Th2 cytokines to reduce hyper-sensitivity. You already know that luteolin is an effective mast cell stabilizer but did you know rosmarinic acid is a potent anti-viral?  In fact, rosemarinic acid has been shown to be effective against COVID-19. Perilla seed extract works on mucus membranes, so it can help with lung inflammation and asthma as well other mucosal membranes like the sinuses and gut. It has also been shown to help people sweat and can help reduce muscle spasms. 
    Recommended Brand: Pure Encapsulations Perilla Extract
    Recommended Dose: Start with  150mg once daily and work up to 300mg 3 times/day

  4. Pycnogenol - is pine bark extract, another bioflavonoid that can be effective as a mast cell stabilizer and anti-histamine. This is often a good choice when quercetin and/or luteolin are not tolerated well which is fairly common as this uses a different liver pathway compared to quercetin and luteolin so those who are phenol sensitive may tolerate this better. 
    Recommended Brand: Pure Encapsulations Pycnogenol
    Recommended Dose: Start with 50mg once daily and work up to 100mg 3 times/day

  5. Fisetin - another potent bioflavanoid that is a mast cell stabilizer but also has anti-coagulant properties. This means it can help to improve blood flow which helps to oxygenate your cells, improves nutrient absorption, and makes detoxification more effective. It has been shown to help reduce neurological inflammation and is neuro-protective.
    Recommended Brand: Life Extension Bio-Fisetin
    Recommended Dose: Start with 1 capsule/day and work up to 1 capsule, 3 times/day

  6. Stinging Nettles Leaf- has been shown to inhibit leukotriene release from mast cells. Leukotrienes are a mediator that often gets triggered from salicylate and phenol sensitivity. It can also help to reduce lung inflammation and asthma as well as skin rashes and itching. I've also clinically observed that it tends to help with irritability and anxiety as well!
    Recommended Brand: Gaia Nettle Leaf
    Recommended Dose: Start with 250mg once daily and work up to 500mg 3 times/day

  7. Vitamin C - can be effective as an anti-histamine, however I find that ascorbic acid products are not often well tolerated by MC patients so I typically recommend that clients try a Vitamin C sourced from tapioca.
    Recommended Brand: Ecological Formulations Vitamin C-1,000
    Recommended Dose: 1,000mg up to 3 times daily

  8. Evening Primrose Oil - has been shown to lower prostaglandins which are another mediator that gets released from mast cells. I find it helps with sleep, anxiety, and sometimes pain. 
    Recommended Brand: Body Bio Evening Primrose Oil
    Recommended Dose: 1,500mg once daily at bedtime

  9. DAO Enzyme or Xylanase Enzyme - while these enzymes are not mast cell stabilizers or anti-histamines, they do help to break down histamine and phenol based compounds in the gut and can be effective in reducing reactions to foods especially.

    DAO is used for those who have histamine intolerance and a mutation on their DAO or HNMT enzymes. I like Diem Histamine Digest**, formerly called Umbrellex brand DAO. I find this formulation to be the cleanest of all the DAO products out there.
    Recommended Dose: 1 capsule prior to each meal. 

    **To order Diem Histamine Digest, click here. 

    Xylanase is an enzyme used to help break down phenol based compounds like salicylates that many mast cell people are reactive to.
    Recommended Brand: Houston Enzymes No-Fenol (available on Amazon)
    Recommended Dose: 1 capsule prior to each meal

  10. Milk Thistle - is a natural mast cell stabilizer, also helps to support liver and gallbladder detox.  This is not recommended for those that have a ragweed allergy. 
    Recommended Brand: Gaia Brand
    Recommended Dose: 400mg twice daily

  11. Butterbur - this is a natural anti-histamine that works similarly to H1 blockers Zyrtec or Allergra. This can be especially helpful for brain related symptoms like brain fog, anxiety, and migraines. 
    Recommended Brand: Integrative Therapeutics Petadolex
    Recommended Dose: 50mg 2-3 times daily

  12. Feverfew - this is a natural mast cell stabilizer that supports healthy mucous membranes and can improve cranial blood vessel integrity. It can be very effective for headaches and migraines related to mast cell and histamine issues.
    Recommended Brand: Vital Nutrients Feverfew
    Recommended Dose: 1-2 capsules up to twice daily

  13. Baical Skullcap (Chinese Skullcap)- This herb can be very helpful in lowering neurological inflammation and can help with insomnia, anxiety, and depression. It is a natural mast cell stabilizer and helps to de-activate retroviruses which I find to be a big root cause of MCAS. 
    Recommended Brand: BioPure Chinese Skullcap, Liftmode Biaclin, & Secrets of the Tribe Huang-Qin Alcohol Free Tincture (you can find these all on Amazon)
    Recommended Dose: Work up to 1 dropper full twice daily or 1 scoop 2-3 times daily

  14. L. theanine or GABA - l. theanine is an amino acid that is a precursor to GABA, a calming neurotransmitter. While these are not directly natural anti-histamines, they do help to calm and balance the nervous system which in turn helps to lower MCA.  These are excellent tools to reduce anxiety, irritability, depression, insomnia, and nervous system overstimulation. 
    Recommended Brand: Pure Encapsulations GABA or L-theanine
    Recommended Dose: GABA - 700mg up to 3 times/day; l-theanine - 250-500 up to 3 times/day

  15. Licorice Root or DGL - either of these forms of licorice root can provide natural anti-histamine support, they work on H2 receptors and can be helpful for symptoms like: flushing, GERD/reflux/heartburn, and throat inflammation.
    Recommended Brand: Designs for Health DGL Synergy Chewable Tablets, Vital Nutrients DGL Powder, or Pure Encapsulations DGL Plus
    Recommended Dose: Up to 1 chewable just after each meal + at bedtime or 1 scoop powder 3 times daily

You can order these supplements at 20% off retail pricing by accessing my online supplement dispensary and setting up an account - just click the button below.  
CLick here to Access my online supplement dispensary
These go-to,  natural mast cell stabilizers can be used in combination with pharmaceuticals like ketotifen, cromolyn, singular, and over the counter anti-histamines like Benadryl if needed. I highly recommend working with an experienced practitioner who can help you choose the products that meet your needs best.

Always keep in mind these anti-histamines and mast cell stabilizers are not going to fix the underlying, or root problem(s) that are causing the MCA symptoms. They will simply help to lower reactions and calm the immune response down so that you can start to treat the underlying reasons your mast cells are over-stimulated in the first place. 

If you want to learn more about my approach for reducing MC reactions and improving root cause treatment tolerance and effectiveness, check out my free online webinar. ​
References:
  1. SharmaSC, Sharma S, Gulati OP, “Pycnogenolinhibits the release of histamine from mast-cells,”PhytotherRes. 2003 Jan;17(1):66-99
  2. Kimata M, ShichijoM, Miura T, Serizawa I, Inagaki N, Nagai H. Effects of luteolin, quercetin and baicalein on immunoglobulin E-mediated mediator release from human cultured mastcells.ClinExpAllergy. 2000b;30:501–508. [PubMed]
  3. Park HH, Lee S, Son HY, Park SB, Kim MS, Choi EJ, et al. Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast-cells. Arch Pharm Res. 2008;31:1303–1311.[PubMed]
  4. Kim B-R, SeoH-S, Ku J-M, et al. Silibinininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  5. ChapowalA. PetasitesStudy Group. Randomisedcontrolled trial of butterbur and cetirizine for treating seasonal allergic rhinitis. BMJ 2002;324:144-6.
  6. Hayes, N. A. and Foreman, J. C. The activity of compounds extracted from feverfew on histamine release from rat mast-cells. J Pharm Pharmacol1987;39(6):466-470
  7. Hsieh et al. Baicalein inhibits IL-1ß- and TNF-a-induced inflammatory cytokine production from human mast-cells via regulation of the NF-?B pathway. ClinMolAllergy. 5: 5. 2007.
  8. TheoharidesTC, Patra P, Boucher W, et al. Chondroitin sulphateinhibits connective tissue mast-cells. British Journal of Pharmacology. 2000;131(6):1039-1049. doi:10.1038/ sj.bjp.0703672.
  9. Ro JY, Lee BC, Kim JY, et al. Inhibitory mechanism of aloe single component (alprogen) on mediator release in guinea pig lung mast-cells activated with specific antigenantibodyreactions. J PharmacolExpTher. 2000;292:114–121. 73.
  10. Kim B-R, SeoH-S, Ku J-M, et al. Silibin ininhibits the production of pro-inflammatory cytokines through inhibition of NF-κB signaling pathway in HMC-1 human mast-cells. Inflammation. Research. 2013;62(11):941-950. doi:10.1007/s00011-013-0640-1.
  11. Kim NH,JeongHJ, Kim HM. Theanine is a candidate amino acid for pharmacological stabilization of mast-cells. Amino Acids. 2011;42:1609–1618.
  12. Theoharides,TheoharisC., and Leonard Bielory. “Mast-cells and mast-cell mediators as targets of dietary supplements.” Annals of Allergy, Asthma & Immunology 93.2 (2004): S24-S34.
40 Comments
Sharon Carpenter
9/28/2018 01:19:35 pm

Billie, your info is short and powerful. I really love what your putting out and gain from the knowledge. I like it better than Chris Kresser.
Great job.

Reply
Billie Shellist
10/1/2018 11:37:25 am

Thanks for the great feedback Sharon!

Reply
Justin
11/19/2018 03:14:36 pm

Do you have a recording of the webinar?

Reply
Billie Shellist
11/21/2018 07:21:56 am

Hi Justin, Yes I do have the webinar recorded. Here is a link to listen to the recording:https://www.functionaldiagnostichealing.com/mcas-webinar-recordings.html

Reply
S
12/29/2019 10:14:35 pm

Did you ever make that blog post about common root causes of MCAS/Histamine Intolerance?

Reply
Billie Shellist
12/30/2019 06:16:52 am

Hello S - I dont have a blog, but do have a recorded webinar on MCAS that includes a complete discussion on the root causes. Click this link here to check that out:https://www.functionaldiagnostichealing.com/mastcellactivationwebinar.html

Reply
Penny Jean Wilson
5/16/2020 02:16:23 pm

Billie,
I have been doing a ton of research into mast cell stabilizers in covid 19. I would love to share some info with you. I am a retired ccu nurse with mast cell activation disorder and eosinophilic asthma with multiple respiratory failures so I was at huge risk for critical covid19 infection and boy did I get it. I vlogged my entire journey on facebook and have now dedicated most of my time to track this little virus down to it's first actions when it enters the lungs....as far as I can tell...mast cell activation. This mast cell activation normally would be exactly whats needed to fight this thing, but the virus exploits the chemicals created in the mast cell reaction to prime the cells for entry and to damage dendritic cells so they can't sound the alarm for help. Then the virus sets up house like a non-paying unevictable tenant. I would love to hear your thoughts.

Reply
Billie
5/17/2020 06:41:25 am

HI Penny,
I'd love to hear more about your story and the information you've learned. Please email me at functionaldiagnostichealing@gmail.com

Reply
Amy Plath
5/26/2020 06:05:39 am

Penny - I would love to hear your ideas, too. Can you link your vlog or possibly contact me at plathtones@gmail.com. Many thanks!

Reply
Sarah
8/4/2020 08:18:37 pm

Penny, I'd love to hear more from you about this as well. My medical training is limited (emergency medicine) so I don't have near the insight that you do. But I have MCAD and have contracted COVID twice. It has been quite the journey, to say the least. And the mast cell impact has been substantial. I searched for you in Facebook, because I'd love to see your vlogs, but wasn't able to find you. And you don't seem to be in the MCAS/COVID Facebook group either. If you're willing, would you reach out and share your vlog? I'd like to compare stories. venmk@hotmail.com is the best way to reach me.

Reply
christopher tishlias
1/11/2021 11:39:58 pm

Hi Pennie,

I have MCAs and got Covid as well in March & am still dealing with the suffering from that. Would love to share stories, info, & guidance. ctishlias@yahoo.com

Reply
Thanh Tran
11/27/2021 06:25:48 pm

Hi, Penny. How are you?
I can't find you on Facebook. I have been suffering from Covid MCAS since July of last year and it's getting worse. Lost a ton of weight (unintentionally), can't eat anything without feeling sick to the stomach, bedridden atm. Would love to hear from you.

Reply
Ann
9/8/2020 02:53:21 pm

I purchased herpes herbal medicine and received it within 7 days and used it as prescribed, I tested negative within 3 weeks use, do not loose hope to contact him early If you need help meet him on his email address dr,chalaherbalhome@gmail.com

Reply
Amy Smith
11/14/2020 12:55:22 pm

I desperately need help with histamine intolerance/possibly mast cell activation syndrome. I am fighting for my life right now, and I need help figuring out what to do to get better. I need help immediately please. I have been to four doctors, the ER, tried multiple approaches, and I am not getting better. i seem to be sensitive to everything. I know that you are booked up, but I am begging for help. I know that you want to help people...please help me. I would love to have a consultation as soon as possible. I am just struggling so much! Thank you for your time and consideration!

Reply
Ann Meadows
9/2/2022 07:05:44 pm

Had minor symptoms off and on all my life but doctor said was bronchitis. At age 40 was diagnosed with Acute Asthma and treated with slim changes for next 15 year, my health consistently deteriated. Age 50 for next 6 years with abundance of the symptoms of MCAD but not yet diagnosed had 4 anaphylaxis episodes with cardiac arrest and did 3 times....once each year for 4 of those six years. Without intabation I would have died. During those six years had mini strokes symptoms and hospitalized. Doctors had no clue because test came back clean. I finally talked them into checking for food and environmental allergies that I had been asking for over 10 years. I was allergic to over 80% of food from all groups. Look up symptoms of MCAD that was me. Even certain water with inadequate ph levels would trigger anaphylaxis. Took me 3 years to figure out how to cook and what to eat again. First time I went grocery shopping it took over 3 hours reading labels for allergy ingredients. The cost was double and not much to eat. By this time I had stopped taking many medication cause always had issues. In 2016 my last anaphylaxis episode I had enough and made a life altering change. Saw a Holistic Specialist that ran test from the core of my body to the outside skin. Blood...20 vials...every test you can get from blood data, stool, urine, hair cut samples, she viewed my previous medical records from every doctor. I had MCAD, Alpha Gayle, Dysbolia, multiple vitamin and enzyme deficiencies, 2 tick diseases, plus many others cell benefactors that has started to deplete. All of this was causing my cells to see every thing that intered my body from all possibilties as a threat and instead of protecting and healing was throwing out warning signs and killing me by causing anaphylaxis shock and by this time within 5 minutes. It has been 6 years Im now 62. Doing shockingly well. Doctors are stund. My life has deeply changed but Im able to enjoy again with restrictions. Remember you must find out the cause. I read all I can find about MCAD that effects 80% of my body from head to toe. With all the food, physical triggers, and environmental allergies it makes it very difficult to eat and have a productive life ...But Im doing it! Yes, I also got Covid. Had bad flu symptoms, stabbing feeling in brain and put me in deep depression for 2 months. Praise God did not effect my lungs. But worked through it. Treated myself. Doubled up on all natural suppliments and did my own healing regiment and took the time to rest. It is important to educate yourself. Get a Holistic Specialist or a doctor that is receptive to natural healing. They must have education in this field. I took online flyers to all my other doctors to help educate them. Everyone must be aware. Understand as best possible. They must be aware of your do's and dont's! Trust me....MCAD does not like medicine among many others triggers. I have helped many with MCAD through providing education and direction. Send me an email and we can make arrangements to talk. Too much to type. I could have made this text 5 xs longer with all my information. Lets get started. annabelldm@gmail.com

Reply
Babsi
1/5/2021 08:50:58 am

Which of these natural antihistamines can be taken with salicylat intolerance?

Reply
Ann Meadows
9/2/2022 07:09:28 pm

Babsi, go online in search box and ask that same question. It should show up. Schroll down and search.

Reply
Billie Shellist
1/6/2021 07:55:30 am

If you are salicylate sensitive, the items I recommend starting with are DAO, No-Fenol Enzymes, Nettle Leaf, Vitamin C, Pycnogenol, Baikal Skullcap, L-theanine and GABA. The ones you are less likely to tolerate would be quercetin and luteolin.

Reply
Kaleigh link
2/3/2021 09:49:07 am

Hey Billie!

Thanks for the great post! Though I'm already on several of these I love reading the description and making me feel more empowered with reinforcing the info in my mind!

Reply
Mohamed link
2/19/2021 01:43:59 pm

phenol in mirica .dr tc said lutoline very little.so whT phneol cause damage in lutoline.
also can gaba supplements work

Reply
Melissa
2/27/2021 12:15:52 am

Is epstein barr considered a retrovirus?

Reply
Billie Shellist
3/3/2021 07:18:50 am

No, EBV is not a retrovirus

Reply
Melissa
2/28/2021 07:29:01 pm

What was the homeopathic you suggested in your video. Its hard to understand it clearly. Most homeopathics have odd names so im trying to be sure I heard what I heard. Lol

Reply
Billie Shellist
3/3/2021 07:19:37 am

The homeopathic I talked about that can help modulate immune function and reduce the cell danger response is Suramin Homeopathic

Reply
Kelly
1/26/2022 02:27:35 pm

What potency for the Suramin homeopathic? Thanks

Ronda Jones
1/8/2023 03:44:00 pm

I have been having difficulty finding Suramin Homeopathic. It seems the medicine is not available in the United States. Do you know where it can be purchased?

Elle Bee
3/12/2021 05:01:43 pm

I am wondering if any of these are made using corn. Corn is an allergen, severe. Also, if you are allergic to things like apples and latex foods... are any of these things you can have?

Reply
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Reply
Leonard siracusa
5/8/2021 11:14:32 pm

I am pretty sure I have mast cell. At the least a severe histamine intolerance but I get terrible panic attacks from breathing cleaning products and scents, and I have had terrible issues since I had a reaction to an antibiotic two years ago. My biggest issue that I worry about is my heart rate gets funny , it really runs fast. Exercise seems to be a trigger, some foods. And my bp seems to be all over and Sensitive. Any of these other than maybe l-Theanine that might be used to help a histamine induced rapid heart rate?

Reply
GHO-AHK CORPORATION link
6/22/2021 12:43:47 am

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Megan
7/25/2021 07:28:27 pm

Do you know if DGL licorice contains salicylates? I know that regular licorice does, and am wondering if the removal of glycyrrhizin makes it safe. I'm looking for something to treat gastritis that is low salicylate and oxalate and it's proving very difficult. I have the gastritis from a bad reaction to salicylates.

Reply
leonard shirin link
8/22/2021 09:00:08 am

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Addie
12/6/2021 12:54:14 pm

Can Enzymedica digestive enzymes be taken along with No-Fenol enzyme. Please kindly let me know. Thanks

Reply
CORAL SCAIFE
12/12/2021 05:35:02 am

I CONSUMED TOO MUCH BENZOLATES THEN BECAME SALICYLATE INTOLERANT. I PUT MY FEET IN A BUCKET WITH WARM WATER AND EPSOM SALTS EACH NIGHT AND GOT BACK ON MY FOOD.

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    Billie Shellist, FDN-P

    I practice functional nutrition, an approach that allows me to look at your entire health history and help you find the "root causes" of your chronic health complaints.  

    ​This cuts out the trial and error process and helps you get real symptom relief and resolution!


    Food is medicine and knowledge is power -I hope you enjoy my anti-inflammatory recipes which are gluten, dairy, and soy free as well as very low grain and sugar.  

    If you'd like to heal from the root cause(s) of your chronic symptoms,  try starting with a complimentary 15-minute consultation.  Click here to request your free session.


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